Glycyrrhizic acid ammonium salt CAS#53956-04-0
Extremely high sweetness — About 200 times sweeter than sucrose, allowing use in small amounts.
Wide application — Commonly used as a sweetener in various food products including canned meats, candies, and beverages.
Health benefits — Exhibits anti-inflammatory and anti-allergic effects without typical corticosteroid side effects.
Liver enzyme interaction — Strong affinity for hepatic sterol-metabolizing enzymes, helping regulate cortisol and aldosterone activity.
Ammonium Glycyrrhizinate has an intense sweet taste, approximately 200 times sweeter than sucrose. It is widely used as a sweetener in food additives, found in products like canned meats, seasonings, candies, biscuits, preserved fruits, and beverages. Monoammonium glycyrrhizinate has a strong affinity for hepatic sterol-metabolizing enzymes (ref: Chemicalbook), which helps inhibit the inactivation of cortisol and aldosterone. When administered, it produces notable glucocorticoid-like effects, such as anti-inflammatory and anti-allergic properties, as well as protection for membrane structures, without the typical side effects associated with corticosteroids.
Parameters
Melting point | >200°C (dec.) |
Boiling point | 768.56°C (rough estimate) |
density | 1.1846 (rough estimate) |
FEMA | 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
refractive index | 49 ° (C=1.5, EtOH) |
storage temp. | 2-8°C |
solubility | Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. |
form | Powder or Crystals |
color | Yellow to yellow-green |
Odor | bland |
optical activity | [α]20/D +48±4°, c = 1% in ethanol: water (1:1) |
BRN | 3897076 |
Stability: | Hygroscopic |
InChIKey | ILRKKHJEINIICQ-YDYGGSECSA-N |
LogP | -0.9 |
CAS DataBase Reference | 53956-04-0 |
EPA Substance Registry System | .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0) |
Safety Information
RIDADR | UN 3077 9 / PGIII |
WGK Germany | 2 |
RTECS | LZ6500000 |
F | 3-10 |
HS Code | 29389090 |
Ammonium Glycyrrhizinate is utilized in the creation of polyion complex nanocarriers, which can serve as a model for designing other negatively charged, water-soluble drugs, particularly those related to anti-inflammatory treatments. Glycyrrhizic acid ammonium salt, derived from licorice flavonoids, acts as a flavoring and sweetening agent. It offers a subtle licorice taste along with a strong, smooth sweetness. This compound is soluble in water, glycerin, and propylene glycol, and exhibits good thermal stability, although it can degrade with prolonged heating. It remains stable within a pH range of 3.5–9 but may precipitate below a pH of 3.5. It is commonly used in beverages, desserts, confectionery, soups, and dressings.
