Propylene glycol CAS#57-55-6
High Purity: Over 99.5% purity, ensuring superior quality for various applications.
Pharmaceutical Compliance: Meets global pharmacopeia standards, serving as a safe low-endotoxin solvent.
Cosmetic Safety: OECD 439-certified as a low-irritant humectant for safe cosmetic use.
Versatile Industrial Use: Effective as an antifreeze carrier and solvent in industrial applications, with a low-toxicity formula.
Propylene Glycol USP/EP/FCC (CAS 57-55-6) is a high-purity liquid solvent and humectant with a purity greater than 99.5%, meeting global pharmacopeia standards. As a USP-grade pharmaceutical excipient, it is used as a low-endotoxin (≤0.5EU/ml) injection solvent. In cosmetics, it serves as a low-irritant humectant, certified by OECD 439. For food processing, the FCC-grade version functions as an antifreeze carrier (21 CFR 184.1666). Its low-toxicity antifreeze properties, with a freezing point of -59°C (ASTM D1384), make it suitable for industrial applications. Technical documentation is available.
Propylene glycol Chemical Properties
Melting point | -60 °C (lit.) |
Boiling point | 187 °C (lit.) |
Density | 1.036 g/mL at 25 °C (lit.) |
Vapor density | 2.62 (vs air) |
Vapor pressure | 0.08 mm Hg ( 20 °C) |
Refractive index | n20/D 1.432(lit.) |
FEMA | 2940 | PROPYLENE GLYCOL |
Fp | 225 °F |
Storage temp. | Store at +5°C to +30°C. |
Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
Pka | 14.49±0.20(Predicted) |
Form | Viscous Liquid |
Color | APHA: ≤10 |
Specific Gravity | 1.038 (20/20℃)1.036～1.040 |
PH | 6-8 (100g/l, H2O, 20℃) |
Odor | at 100.00 %. odorless very slight alcoholic |
Odor Type | odorless |
Optical Rotation | -0.11° (C=1.00g/100ml, CHCL3) |
Biological source | synthetic |
Explosive limit | 2.4-17.4%(V) |
Water Solubility | miscible |
Sensitive | Hygroscopic |
Merck | 14,7855 |
JECFA Number | 925 |
BRN | 1340498 |
Dielectric constant | 32.0 |
InChIKey | DNIAPMSPPWPWGF-UHFFFAOYSA-N |
LogP | -0.92 |
Surface tension | 35.44mN/m at 298.15K |
CAS DataBase Reference | 57-55-6(CAS DataBase Reference) |
NIST Chemistry Reference | Propylene glycol(57-55-6) |
EPA Substance Registry System | Propylene glycol (57-55-6) |
Safety Information
Safety Statements | 24/25 |
WGK Germany | 1 |
RTECS | TY2000000 |
Autoignition Temperature | 779 °F |
TSCA | Yes |
HS Code | 29053200 |
Hazardous Substances Data | 57-55-6(Hazardous Substances Data) |
Toxicity | LD50 orally in Rabbit: 19400 - 36000 mg/kg LD50 dermal Rabbit 20800 mg/kg |
Propylene Glycol (CAS 57-55-6) is a key multifunctional ingredient widely used across industries due to its excellent solubility and low toxicity. In the pharmaceutical sector, it serves as a USP-approved solvent for oral and transdermal formulations with minimal endotoxin content (≤0.5 EU/ml). In cosmetics, it is recognized for its OECD 439-certified moisturizing properties, enhancing hydration in lotions and serums. For food processing, FCC-grade PG is utilized as a safe antifreeze carrier (21 CFR 184.1666), while industrial applications benefit from its efficient antifreeze capabilities, with a freezing point of -59°C (ASTM D1384). Technical documentation is available for industry-specific needs.
