Musk Ketone CAS# 81-14-1
Pleasant and Classic Musk Aroma: Ketone musk features a sweet, animal-like musk fragrance that adds depth and richness to fragrance formulations.
Long-Lasting Scent Performance: Its soft yet persistent aroma provides excellent longevity, making it ideal for perfumes and fragrance products.
Stable Physical and Chemical Properties: With a relatively high melting point and boiling point, ketone musk demonstrates good thermal and chemical stability.
Good Compatibility with Fragrance Materials: It is soluble in benzyl benzoate, animal oils, and essential oils, allowing easy blending with a wide range of fragrance ingredients.
Musk Ketone CAS# 81-14-1
Musk Ketone is an important synthetic fragrance compound with the molecular formula C₁₄H₁₈N₂O₅ and a molecular weight of 294.303. It appears as pale yellow crystals, typically in powder or flake form, and is characterized by a sweet, animal-like musk aroma that is soft and long-lasting.
Musk Ketone is insoluble in water and ethanol, but readily soluble in benzyl benzoate, animal oils, and essential oils. It has a melting point of 135–139 °C, a density of approximately 1.2 ± 0.1 g/cm³, and a boiling point of 369.0 ± 42.0 °C at 760 mmHg. Its flash point is 153.2 ± 20.7 °C.
| Product Name: | Musk ketone |
| Synonyms: | 2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene;3',5'-Dinitro-4'-tert-butyl-2',6'-dimethylacetophenone;3, 5-Dinitro-4-t-butyl-2, 6-dimethylacetophenone;Ketone Moschus,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Musk ketone;Musk ketone,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Ketone Moschus;Musk ketone 0;Ketone Moschus >=97.0% (N);1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon |
| CAS: | 81-14-1 |
| MF: | C14H18N2O5 |
| MW: | 294.3 |
| EINECS: | 201-328-9 |
| Product Categories: | PP;KetonesAlphabetic;Analytical Standards;AromaticsAnalytical Standards;Chemical Class;Life Sciences Standards;Aromatic Acetophenones & Derivatives (substituted);M;METI - MZChromatography;Natural Compounds;Natural CompoundsAnalytical Standards;Nitro CompoundsChemical Class;OtherMore...Close...;Cosmetics;Food & Feed ADDITIVES;Organics |
| Mol File: | 81-14-1.mol |
Musk ketone Chemical Properties
| Melting point | 134-137 °C |
| Boiling point | 436.08°C (rough estimate) |
| Density | 1.2051 (rough estimate) |
| Vapor pressure | 0.001Pa at 25℃ |
| Refractive index | 1.5110 (estimate) |
| Fp | 2 °C |
| Storage temp | 2-8°C |
| Solubility | DMSO : 250 mg/mL (849.47 mM; Need ultrasonic) |
| Form | Solid |
| Color | White to off-white |
| Odor | at 10.00 % in benzyl benzoate. fatty musk soapy dry floral powdery |
| Odor Type | musk |
| Biological source | synthetic |
| Water Solubility | Insoluble (<0.1 g/100 mL at 20 ºC) |
| BRN | 2062638 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| InChIKey | WXCMHFPAUCOJIG-UHFFFAOYSA-N |
| LogP | 4.24 at 25℃ |
| CAS DataBase Reference | 81-14-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,6-Dimethyl-3,5-dinitro-4-t-butylacetophenone(81-14-1) |
| EPA Substance Registry System | Musk ketone (81-14-1) |
Product Usage
Musk Ketone is widely used as an important synthetic fragrance and fixative. In the flavor and fragrance industry, it is commonly used in the formulation of various fragrance blends to provide products with a distinctive and long-lasting musky scent, particularly in sweet, oriental, and heavy fragrance types.
In the cosmetics industry, it is frequently incorporated into perfumes, powders, creams, and similar products. It not only enhances the overall fragrance profile but also helps the scent remain on the skin for a longer period.
In addition, although its use in the pharmaceutical field is limited due to potential toxicity and environmental concerns, pharmacological studies indicate that it can stimulate the central nervous system, respiratory center, and heart. It may also promote glandular secretion, dilate coronary arteries to increase coronary blood flow, and contribute to improved blood circulation, reduction of swelling, and relief of pain.
