Arbutin CAS#497-76-7
Effective tyrosinase inhibition — Strongly inhibits human tyrosinase activity, helping to reduce melanin production.
Powerful antioxidant — Protects cells from free radical-induced damage and prevents hemolysis.
Anti-inflammatory effects — Reduces inflammatory cytokines such as IL-1β, IL-6, and TNF-α in lung tissue and serum.
Widely used in skin care — Commonly applied in treatments for hyperpigmentation disorders.
Arbutin is a glycosylated form of hydroquinone found in Arctostaphylos plants, known for its various biological activities, including inhibiting tyrosinase, offering antioxidant properties, and providing anti-inflammatory effects. It effectively inhibits human tyrosinase activity in crude tyrosinase solutions isolated from human melanocytes (IC50s = 5.7 and 18.9 mM for L-tyrosine and L-DOPA substrates, respectively), as well as in intact melanocytes (IC50 = 0.5 mM). Arbutin (50 μM) also inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes and protects cultured human skin fibroblasts from AAPH-induced cell viability loss at concentrations above 125 μM. In a rat model of acute lung injury induced by LPS, arbutin (50 mg/kg) reduces the levels of IL-1β, IL-6, and TNF-α in lung tissue and serum. Arbutin-containing formulations are commonly used in the treatment of hyperpigmentation disorders.
Parameters
Melting point | 195-198 °C |
alpha | -64 º (c=3) |
Boiling point | 375.31°C (rough estimate) |
density | 1.3582 (rough estimate) |
refractive index | -65.5 ° (C=4, H2O) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | H2O: 50 mg/mL hot, clear |
form | Solid |
pka | 10.10±0.15(Predicted) |
color | White |
optical activity | [α]/D -64.0±2.0°, c = 3 in H2O |
biological source | synthetic or plant |
Water Solubility | 10-15 g/100 mL at 20 ºC |
Sensitive | Hygroscopic |
Merck | 14,773 |
BRN | 89673 |
Stability: | Stable. Hygroscopic - store under dry nitrogen. |
InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
LogP | -1.350 |
CAS DataBase Reference | 497-76-7(CAS DataBase Reference) |
EPA Substance Registry System | .beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7) |
Safety Information
Hazard Codes | Xn |
Risk Statements | 20/21/22-36/37/38 |
Safety Statements | 22-24/25-36-26 |
WGK Germany | 3 |
RTECS | CE8863000 |
F | 3-10-23 |
HS Code | 29389090 |
Hazardous Substances Data | 497-76-7(Hazardous Substances Data) |
Diuretic and anti-infective agents for the urinary system. Stabilizer in color photographic development. Used for whitening, freckle reduction, and hair care in cosmetic formulations.
