Pancreatin CAS#8049-47-6
Multi-enzyme complex – Contains a powerful blend of pancreatic amylase, protease, and lipase for comprehensive digestive support.
High enzymatic activity – Efficiently converts at least 25 times its weight of starch and casein, demonstrating strong catalytic performance.
Optimal activity in neutral to mild alkaline media – Performs best under physiological pH conditions, making it highly suitable for digestive and pharmaceutical applications.
Rich in enzyme precursors – Also contains trypsinogen, chymotrypsinogen, and carboxypeptidase, providing broader enzymatic functionality after activation.
Pancreatin CAS#8049-47-6
Pancreatin is a substance derived from the fresh pancreas of hogs or oxen and contains a mixture of enzymes, mainly pancreatic amylase (amylopsin), protease, and pancreatic lipase (steapsin). It is capable of converting not less than 25 times its weight of USP potato starch reference standard into soluble carbohydrates and not less than 25 times its weight of casein into proteoses. It performs best in neutral or slightly alkaline media, while excessive acidity or alkalinity will inactivate it.
Pancreatin may be prepared by extracting the fresh gland with 25% alcohol or water, followed by precipitation with alcohol. In addition to the principal enzymes, it also contains trypsinogen, which can be activated by intestinal enterokinase; chymotrypsinogen, which is converted into chymotrypsin by trypsin; and carboxypeptidase.
It is widely used for the predigestion of food and the preparation of hydrolysates. However, its oral enzymatic activity may be limited, as the enzymes can be digested by pepsin and gastric acid, although a portion may pass unchanged into the intestines. Even with enteric coating protection, its overall contribution to digestion may remain limited.
Pancreatin Chemical Properties
| Bulk density | 400kg/m3 |
| Density | 1.4-1.52 |
| Vapor pressure | 0Pa at 25℃ |
| Storage temp | -20°C |
| Solubility | Soluble or partly soluble in water forming a slightly turbid solution; practically insoluble in ethanol (96%) and in ether . |
| Form | powder |
| Color | beige |
| PH | 5-6 (20°C, 10g/L in H2O) |
| Biological source | Porcine pancreas |
| Water Solubility | Soluble in water. Insoluble in alcohol and ether. |
| Merck | 137075 |
| Specific Activity | 8× USP specifications |
| Stability | Stable. Incompatible with alcohols, strong acids. |
| Cosmetics Ingredients Functions | HAIR CONDITIONING |
| SKIN CONDITIONING | |
| LogP | -1.3 at 20℃ and pH5.7-5.8 |
| EPA Substance Registry System | Pancreatin (8049-47-6) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42-42/43 |
| Safety Statements | 22-24-26-36/37-37/39 |
| WGK Germany | 1 |
| RTECS | RT9033000 |
| F | 46091 |
| Autoignition Temperature | >360°C |
| TSCA | TSCA listed |
| HS Code | 35079090 |
| Storage Class | 13 - Non Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 |
| Resp. Sens. 1 | |
| Skin Irrit. 2 | |
| Skin Sens. 1 | |
| STOT SE 3 | |
| Hazardous Substances Data | 8049-47-6(Hazardous Substances Data) |
| Toxicity | LD50 orl-rat: >10 g/kg YACHDS 3,2427,75 |
Product Application of Pancreatin CAS#8049-47-6
Pancreatin hydrolyzes starch into dextrins and sugars. Pancreatin derived from porcine pancreas is used in lipase supplementation therapy for the treatment of steatorrhea and pancreatic diabetes. It is also applied in the removal of formalin-fixed tissues from arterial grafts without damaging fiber integrity, and it has additional uses in contact lens applications.
Moreover, pancreatin is used in the treatment of conditions associated with insufficient pancreatic secretions, such as surgical pancreatectomy, pancreatitis, and cystic fibrosis.
