Titanocene dichloride CAS#1271-19-8
Widely Used Organometallic Reagent: Titanocene dichloride is a commonly used reagent in organometallic chemistry and organic synthesis.
Unique Structural Properties: Its tetrahedral coordination structure provides distinct reactivity compared to typical metallocenes.
Potential Pharmaceutical Value: It exhibits anti-tumor activity and has progressed into clinical trials as a chemotherapy candidate.
Stable Solid Form for Handling: As a bright red solid, it allows convenient storage and handling under controlled conditions.
Titanocene dichloride Chemical Properties
| Melting point | 260-280 °C (dec.)(lit.) |
| Boiling point | 355.52°C (estimate) |
| density | 1.6 g/mL at 25 °C(lit.) |
| vapor pressure | 0.002Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | slightly soluble in H2O, benzene; soluble in chloroform,ethanol, toluene |
| form | crystal |
| color | red |
| Specific Gravity | 1.6 |
| Water Solubility | slow decomposition |
| Sensitive | Air & Moisture Sensitive |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| Merck | 149482 |
| Stability: | Stable. Incompatible with strong oxidizing agents. Decomposes in water. Moisture sensitive. |
| LogP | -1.35 at 20℃ |
| CAS DataBase Reference | 1271-19-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Titanocene dichloride(1271-19-8) |
| EPA Substance Registry System | Titanocene dichloride (1271-19-8) |
Safety Information
| Hazard Codes | Xi,T |
| Risk Statements | 37/38-61-40-34-33-36/37/38 |
| Safety Statements | 36-7/8-6A-45-36/37/39-26 |
| RIDADR | UN3261 |
| WGK Germany | 3 |
| RTECS | XR2050000 |
| F | 39742 |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29310095 |
| Hazardous Substances Data | 1271-19-8(Hazardous Substances Data) |
| Toxicity | Titanocene dichloride may cause skin and mucous membrane irritation. The LD50 in mice has been reported as 60 mg/kg (i.p.) and 180 mg/kg (i.v.). In the rat, the LD50 is 25 mg/kg (i.p.). |
Product Application of Titanocene Dichloride CAS#1271-19-8
Titanocene dichloride serves as a highly efficient homogeneous catalyst in reactions such as olefin polymerization and hydrogenation. It can also be used in one-pot synthesis processes, for example, in the preparation of α-methylene-γ-butyrolactone from benzaldehyde and methyl bromoacrylate.
In addition, it functions as an effective hydrogenation catalyst and is primarily applied in polymerization and hydrogenation systems. Owing to its relatively low toxicity and biological activity, it has also been explored for use as an active substance in pharmaceutical applications.
