Tetramethylguanidine CAS#80-70-6
Strong Organic Base Catalyst – Provides high catalytic activity, improving reaction efficiency in various chemical processes.
Versatile Industrial Applications – Widely used in pharmaceutical synthesis, particularly as a co-solvent in the production of cephalosporin antibiotics.
Efficient Polyurethane Catalyst – Serves as an effective catalyst in the manufacture of polyurethane foams.
Enhanced Dyeing Performance – Helps achieve level dyeing for nylon, wool, and protein fibers while improving fabric durability.
Products Description of Tetramethylguanidine CAS#80-70-6
Tetramethylguanidine (TMG) is a strong organic base catalyst that is widely utilized in industrial applications. It is commonly employed as a co-solvent in the synthesis of new cephalosporin antibiotics.
In addition, TMG can function as a catalyst in the production of polyurethane foams. It is also used in the leveling dyeing of nylon, wool, and other protein fibers, helping to enhance dye uniformity and improve the durability of the materials.
Tetramethylguanidine Chemical Properties
| Melting point | -30 °C |
| Boiling point | 162-163 °C (lit.) |
| Density | 0.916 g/mL at 20 °C (lit.) |
| Vapor pressure | 0.2 mm Hg ( 20 °C) |
| Refractive index | n20/D 1.469 |
| Fp | 140 °F |
| Storage temp | Store below +30°C. |
| Solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Pka | 15.20±0.70(Predicted) |
| Form | Liquid |
| Color | APHA: ≤150 |
| PH | 12.7 (10g/l, H2O, 25℃) |
| Relative polarity | 5.5 |
| Odor | mild ammoniacal odor |
| Explosive limit | 1.0-7.5%(V) |
| Water Solubility | miscible |
| Sensitive | Air Sensitive |
| BRN | 969608 |
| Dielectric constant | 23.1 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive. |
| InChIKey | KYVBNYUBXIEUFW-UHFFFAOYSA-N |
| LogP | -0.49 at 20℃ |
| CAS DataBase Reference | 80-70-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N,N,N',N'-Tetramethylguanidine(80-70-6) |
| EPA Substance Registry System | Guanidine, N,N,N',N'-tetramethyl- (80-70-6) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 22-34-20/22-10 |
| Safety Statements | 26-27-36/37/39-45-16 |
| RIDADR | UN 2920 8/PG 2 |
| WGK Germany | 1 |
| F | 46288 |
| Autoignition Temperature | 222 °C |
| Hazard Note | Harmful/Corrosive |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29252000 |
| Toxicity | LD50 orally in Rabbit: 835 mg/kg |
Product Application of Tetramethylguanidine CAS#80-70-6
Tetramethylguanidine is widely used as a strong organic base catalyst and as a co-solvent in the synthesis of new antibiotics, particularly cephalosporin drugs. It can also serve as a catalyst in the production of polyurethane foam. In the textile industry, it is applied in the leveling dyeing of nylon, wool, and other protein fibers to enhance dye uniformity and improve wool durability. In addition, it is mainly used in the synthesis of pharmaceutical compounds such as cefradine.
