1-Chloroisoquinoline CAS#19493-44-8
Valuable Pharmaceutical Intermediate: 1-Chloroisoquinoline is widely used as an important intermediate in pharmaceutical synthesis and fine chemical development.
Suitable for Isoquinoline Derivative Synthesis: The compound can be utilized in the preparation of isoquinoline derivatives such as 1-phenylisoquinoline, supporting diverse synthetic applications.
Efficient Synthetic Versatility: It demonstrates excellent utility in organic synthesis processes and can be prepared from N-vinylbenzamide as a starting material.
Reliable Heterocyclic Building Block: As a chloro-substituted isoquinoline compound, it provides good reactivity and structural versatility for medicinal chemistry and research applications.
Products Description of 1-Chloroisoquinoline CAS#19493-44-8
1-Chloroisoquinoline is commonly used as an intermediate in pharmaceutical synthesis, including in the preparation of compounds such as 1-phenylisoquinoline. It can be synthesized using N-vinylbenzamide as a reaction starting material.
1-Chloroisoquinoline Chemical Properties
| Melting point | 31-36 °C (lit.) |
| Boiling point | 274-275 °C/768 mmHg (lit.) |
| Density | 1.2108 (rough estimate) |
| Refractive index | 1.6342 (estimate) |
| Fp | >230 °F |
| Storage temp | Inert atmosphere,2-8°C |
| Pka | 2.03±0.30(Predicted) |
| Form | Low Melting Solid, Crystals and/or Chunks |
| Color | White to yellow |
| Water Solubility | Insoluble in water. |
| BRN | 2996 |
| InChIKey | MSQCQINLJMEVNJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 19493-44-8(CAS DataBase Reference) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 29334900 |
Product Application of 1-Chloroisoquinoline CAS#19493-44-8
It is applied in manganese-catalyzed coupling reactions involving aryl and alkyl magnesium halides, as well as in palladium-catalyzed coupling reactions with heteroarylboronic acids and esters.
