Cordycepin CAS#73-03-0
Potent Anti-Inflammatory & Neuroprotective Activity: Exhibits significant anti-inflammatory effects and protects hippocampal neurons by inhibiting Aβ-induced apoptosis.
Strong Anticancer Potential: Induces apoptosis across various cancer cell lines, supporting its application in oncology research.
Metabolic Health Benefits: Demonstrates anti-obesity effects and inhibits cellular senescence through activation of AMPK signaling pathways.
Advanced Stem Cell Support: Helps maintain stem cell pluripotency and enhances the efficiency of induced pluripotent stem (iPS) cell generation, making it valuable in regenerative medicine research.
Cordycepin (CAS#73-03-0)
Cordycepin is an adenosine analog characterized by the absence of a hydroxyl group at the 3′ position. It has been shown to inhibit PARP1 and interfere with polyadenylation processes.
Cordycepin exhibits notable anti-inflammatory properties and provides neuroprotective effects by suppressing Aβ-induced apoptosis in hippocampal neurons. It is also capable of inducing apoptosis in various cancer cell lines and demonstrates anti-obesity activity.
In addition, cordycepin can delay cellular senescence through activation of the AMPK pathway. It supports the maintenance of stem cell pluripotency and enhances the efficiency of induced pluripotent stem (iPS) cell generation.
| Product Name: | Cordycepin |
| Synonyms: | CORDYCEPIN;3’-deoxy-adenosin;9-cordyceposidoadenine;3'-dA;Cordycepin from Cordyceps militaris;Cipargamin;9-(3-deoxypentofuranosyl)-9H-purin-6-amine;3'-Deoxyadenosine(cordycepin) |
| CAS: | 73-03-0 |
| MF: | C10H13N5O3 |
| MW: | 251.24 |
| EINECS: | 200-791-4 |
| Product Categories: | Miscellaneous Natural Products;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;73-03-0 |
| Mol File: | 73-03-0.mol |
Cordycepin Chemical Properties
| Melting point | 225-229 °C |
| alpha | D20 -47°; D27 -42° |
| Boiling point | 394.4°C (rough estimate) |
| Density | 1.2938 (rough estimate) |
| Refractive index | 1.7610 (estimate) |
| Storage temp | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Solubility | Soluble in DMSO (up to 25 mg/ml). |
| Rorm | Powder |
| Pka | 13?+-.0.60(Predicted) |
| Color | White to Off-white |
| Biological source | Cordyceps militaris |
| λmax | 260nm(EtOH)(lit.) |
| Merck | 142529 |
| BRN | 35194 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChIKey | OFEZSBMBBKLLBJ-BAJZRUMYSA-N |
| CAS DataBase Reference | 73-03-0(CAS DataBase Reference) |
| EPA Substance Registry System | Adenosine, 3'-deoxy- (73-03-0) |
Product Usage
Cordycepin (CAS#73-03-0) is an adenosine analog that lacks the hydroxyl group at the 3′ position. It functions as an inhibitor of PARP1 and interferes with polyadenylation.
It exhibits anti-inflammatory activity and provides neuroprotection by reducing Aβ-induced apoptosis in hippocampal neurons. Cordycepin also promotes apoptosis in multiple cancer cell lines and demonstrates anti-obesity effects.
Furthermore, it suppresses cellular senescence through activation of the AMPK pathway. It helps preserve stem cell pluripotency and enhances the efficiency of induced pluripotent stem (iPS) cell generation.
