1-Propanethiol CAS#107-03-9
1-Propanethiol is a key chemical intermediate widely used in pharmaceuticals, pesticides, and fine chemicals industries.
Its thiol (-SH) group provides strong nucleophilicity, enhancing its reactivity in chemical synthesis.
It is essential for producing sulfur-containing drugs, including anti-ulcer medications and antibiotics.
It plays an important role in the synthesis of rubber and fragrance compounds.
1-Propanethiol is a sulfur-containing organic compound with the formula C3H8S. At room temperature, it appears as a clear, colorless liquid with a strong odor. Serving as an important chemical intermediate, 1-Propanethiol is extensively utilized in the pharmaceutical, pesticide, and fine chemical industries. Its molecular structure includes a thiol (-SH) group, which provides excellent nucleophilicity, making it a valuable raw material for synthesizing sulfur-containing drugs like anti-ulcer medications and antibiotics. Additionally, it plays a crucial role in the production of rubber and fragrances.
Melting point | -113 °C |
Boiling point | 67-68 °C(lit.) |
Density | 0.841 g/mL at 25 °C(lit.) |
Vapor density | 2.54 (vs air) |
Vapor pressure | 122 mm Hg ( 20 °C) |
Refractive index | n20/D 1.437(lit.) |
FEMA | 3521 | PROPANETHIOL |
Fp | −5 °F |
Storage temp | Store below +30°C. |
Solubility | 1.9g/l |
Pka | pK1:10.86 (25°C) |
Form | Liquid |
Color | Colorless |
Odor | At 0.10 % in propylene glycol. cabbage natural gas sweet onion |
Odor Threshold | 0.000013ppm |
Odor Type | Alliaceous |
Biological source | Synthetic |
Water Solubility | Immiscible |
Key Drug Intermediates
1-Propanethiol serves as the essential synthetic raw material for proton pump inhibitor anti-ulcer drugs such as omeprazole and lansoprazole, where its thiol group plays a crucial role in combining with the drug molecular framework.
Innovative Biomedical Applications
It is utilized as a protein drug modifier to enable site-specific modifications via thiol-disulfide bond exchange, and is also employed in designing active structures of new fungicides to broaden their antifungal spectrum.
High-Efficiency Pesticide Synthesis
1-Propanethiol acts as a vital thio-precursor for organophosphorus insecticides like propylthiophos, directly impacting their effectiveness.
Advanced Polymer Materials
As a specialized rubber vulcanization accelerator, 1-Propanethiol significantly enhances product performance and is used in synthesizing functional polymers that impart unique properties to materials.
Innovations in Electronic Materials
It is an important precursor for semiconductor thin film vapor deposition, a doping modifier for new conductive polymers, and a core synthetic raw material for photoelectric conversion materials.
Breakthroughs in New Energy Technologies
1-Propanethiol serves as a key electrolyte additive in lithium-sulfur batteries to address polysulfide shuttling issues and functions as a catalyst carrier modifier in fuel cells to enhance catalytic efficiency.
