Quinine CAS#130-95-0
Effective Antimalarial Agent – Targets Plasmodium falciparum, a major cause of malaria.
Blood Schizontocidal Activity – Kills parasites within red blood cells.
Versatile Treatment Option – Can be used alone or in combination with other antimalarials.
Natural Origin – Derived from cinchona bark, a traditional medicinal source.
Quinine (CAS#130-95-0) is an alkaloid extracted from the bark of the cinchona tree, known for its blood schizontocidal properties and higher toxicity compared to chloroquine. It is primarily used to treat malaria caused by Plasmodium falciparum, a parasite that invades red blood cells and leads to the onset of malaria. Quinine acts by either destroying the parasite or inhibiting its growth. It can be administered as a standalone treatment or in combination with other antimalarial drugs.
Quinine Chemical Properties
Melting point | 173-175 °C(lit.) |
Alpha | -172 º (c=1, EtOH) |
Boiling point | 462.75°C (rough estimate) |
Density | 1.1294 (rough estimate) |
Bulk density | 110-140kg/m3 |
Vapor pressure | 0Pa at 25℃ |
Refractive index | 1.6250 (estimate) |
Fp | >110°C (>230°F) |
Storage temp | Keep in dark place,Inert atmosphere,Room temperature |
Solubility | H2O: soluble |
Form | Crystalline Powder |
Pka | 8.52(at 25℃) |
Color | White |
PH Range | Blue I uorescence (3.0) to weak violet I uorescence (5.0);Weak violet I uorescence (9.5) to nonI uorescence (10.0) |
PH | 9.0 (0.5g/l, H2O, 20℃) |
Odor Type | odorless |
Optical Rotation | [α]25/D 165°, c = 2 in ethanol |
Water Solubility | slightly soluble |
Sensitive | Light Sensitive |
Hydrolytic Sensitivity | 2: reacts with aqueous acid |
Merck | 14,8061 |
BRN | 91867 |
Major Application | Bird repellents, sunscreen, antimalarial agent, antiviral agent, antitumor agent, drug-coated coronaryagent, antiparasitic agent, treatment of epilepsy, skeletal muscle spasm, drug-coated coronary stent system |
LogP | 3.17 at 25℃ |
CAS DataBase Reference | 130-95-0(CAS DataBase Reference) |
NIST Chemistry Reference | Quinine(130-95-0) |
EPA Substance Registry System | Quinine (130-95-0) |
Beyond its role as an antimalarial agent, quinine is also employed in the treatment of leg cramps, muscle cramps related to kidney failure, hemorrhoids, heart palpitations, and as a pain reliever. However, at elevated concentrations, quinine can become toxic and lead to a condition known as cinchonism, which is characterized by symptoms such as dizziness, hearing impairment, visual disturbances, nausea, and vomiting.
