What is 4-Amino-2,6-dibromopyridine CAS#39771-34-1

39771-34-1 Introduction

4-Amino-2,6-dibromopyridine (CAS#39771-34-1) is a pyridine derivative that appears as a pale yellow crystalline solid, soluble in both water and organic solvents. Owing to its diverse biological activities, it finds wide applications in the pharmaceutical and agrochemical industries. This article provides an overview of its synthesis, properties, and applications.

39771-34-1 Synthesis

The compound can be synthesized by reacting 4-bromo-2,6-dichloropyridine with ammonia in the presence of a palladium catalyst under high temperature and pressure, producing good yields. Another route involves reacting 4-amino-2,6-dichloropyridine with hydrobromic acid in the presence of a reducing agent such as zinc or iron. Both methods are relatively straightforward and can be scaled up for industrial production.

39771-34-1 Properties and Applications

4-Amino-2,6-dibromopyridine exhibits a broad spectrum of biological activities, including antifungal, antibacterial, and anticancer effects. It has demonstrated effectiveness against various fungal and bacterial strains, such as Candida albicans, Escherichia coli, and Staphylococcus aureus. Moreover, this compound has shown potential in suppressing the growth of cancer cells, making it a promising candidate for anticancer drug research and development.

In addition, 4-Amino-2,6-dibromopyridine serves as an important intermediate in the synthesis of pharmaceutical and agrochemical compounds. It can be used to produce a range of pyridine derivatives with diverse biological properties. For instance, it is employed in the synthesis of 4-Amino-2,6-dibromo-3-nitropyridine, which has proven effective against malaria parasites. It is also utilized in the preparation of herbicides and insecticides widely applied in agriculture.

39771-34-1 Safety and Handling

4-Amino-2,6-dibromopyridine is classified as a hazardous chemical and must be handled with caution. It is toxic if swallowed or inhaled and may cause irritation to the skin and eyes. Appropriate safety precautions are required during use, including protective gloves, goggles, and respiratory equipment. The compound should be stored in a cool, dry, well-ventilated area, away from heat sources and incompatible substances.

Conclusion

In summary, 4-Amino-2,6-dibromopyridine is a multifunctional compound with valuable biological activities. Its synthesis is relatively simple, and it plays an important role in the pharmaceutical and agrochemical industries. However, due to its hazardous nature, strict safety measures must be observed during handling and storage.