2-ACP CAS#36936-23-92 Introduction

2-ACP (CAS#36936-23-92) is an important chemical intermediate widely used in pharmaceutical and chemical synthesis.

2-ACP Introduction

2-ACP is a chemical compound with the molecular formula C6H6ClN2. It serves as an important intermediate in the synthesis of various pharmaceuticals and agrochemicals. This article provides an overview of its properties, synthesis methods, applications, and general significance.

Properties of 2-ACP

1. Physical Properties:
2-ACP appears as a white to off-white crystalline powder with a melting point of 110–114°C. It is soluble in organic solvents such as ethanol, methanol, and acetone, but insoluble in water.

2. Chemical Properties:
2-ACP is a heterocyclic compound containing a pyridine ring and an amino group. It exhibits weak basicity and can form salts with acids. In addition, it is prone to nucleophilic substitution reactions at the chloro group position.

Synthesis of 2-ACP

1. From 2,6-Dichloropyridine:
One common synthetic route involves reacting 2,6-dichloropyridine with ammonia in the presence of catalysts such as Raney nickel or palladium on carbon. The process includes hydrogenation, dechlorination, and cyclization steps to obtain 2-ACP.

2. From 2,6-Dichloronicotinic Acid:
Another method uses 2,6-dichloronicotinic acid reacting with ammonia in the presence of reducing agents such as sodium borohydride, also proceeding through a multi-step transformation to yield 2-ACP.

Applications of 2-ACP

1. Pharmaceutical Intermediates:
2-ACP is widely used as an intermediate in the synthesis of antihypertensive, antitumor, and antiviral drugs.

2. Agrochemical Intermediates:
It is also applied in the production of agrochemicals such as herbicides and fungicides.

3. Other Applications:
Additionally, 2-ACP can serve as a building block for other organic compounds, including dyes and pigments.

Conclusion

2-ACP (2-AMINO-5-CHLORO-6-PICOLINE) is a key intermediate widely used in pharmaceutical and agrochemical synthesis. It can be prepared from 2,6-dichloropyridine or 2,6-dichloronicotinic acid via ammonia-based reactions. With its diverse applications across multiple industries, 2-ACP is an important compound in modern chemical research and production.