Diazolidinyl UreaCAS#78491-02-8
Broad-Spectrum Antimicrobial Protection：Diazolidinyl urea effectively inhibits the growth of both bacteria and fungi, providing reliable, wide-ranging preservation for cosmetic and personal care formulations.
Extended Product Shelf Life：By gradually releasing small, controlled amounts of formaldehyde, it protects products from microbial contamination over time, significantly improving stability and storage life.
High Preservation Efficiency at Low Dosage：Its strong antimicrobial performance allows formulators to achieve effective preservation with relatively low usage levels, helping maintain product quality without compromising formulation balance.
Well-Established and Regulated Preservative：Diazolidinyl urea is a widely used, industry-recognized preservative with clear regulatory guidelines, enabling safe and controlled application when properly labeled and formulated.
Diazolidinyl urea (CAS# 78491-02-8) is a common, broad-spectrum antimicrobial preservative in cosmetics, known as a formaldehyde releaser that prevents bacterial and fungal growth, extending product shelf life, but can cause allergic reactions in sensitive individuals, requiring careful labeling and regulation. Its chemical formula is C8H14N4O7 and it appears as a white solid, releasing small amounts of formaldehyde to protect products from contamination.
Diazolidinyl Urea Chemical Properties
| Boiling point | 421.04°C (rough estimate) |
| Density | 1.4734 (rough estimate) |
| Vapor pressure | 0Pa at 20℃ |
| Refractive index | 1.6590 (estimate) |
| Storage temp. | 2-8°C |
| Solubility | Water (Slightly) |
| Form | Solid |
| Pka | 11.22±0.46(Predicted) |
| Color | White to Off-White |
| Water Solubility | 1000g/L at 20℃ |
| Merck | 143,000 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | SOROIESOUPGGFO-UHFFFAOYSA-N |
| LogP | 0.9 at 20℃ |
| CAS DataBase Reference | 78491-02-8(CAS DataBase Reference) |
| EPA Substance Registry System | Diazolidinylurea (78491-02-8) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| WGK Germany | 2 |
| RTECS | YS2717000 |
| HS Code | 29339900 |
| Toxicity | LD50 orally in rats: 2.57 g/kg; dermally in rabbits: >2.0 g/kg (Berke, Rosen) |
Product Application of Diazolidinyl Urea CAS#78491-02-8
Diazolidinyl urea is suitable for use in both leave-on and rinse-off formulations, including creams, lotions, shampoos, conditioners, liquid cosmetics, and eye makeup products. It has been officially approved for use in both the United States and the European Union. The typical recommended dosage ranges from 0.1% to 0.3%, and it is advisable to incorporate it at processing temperatures below 50 °C to maintain stability. For improved preservative performance, it can be used in combination with parabens and IPBC to achieve a synergistic antimicrobial effect.
