Gentamicin sulfate CAS#1405-41-0
1. Broad-Spectrum Antimicrobial: Effective against Gram-negative organisms like E. coli, Shigella, and Pseudomonas aeruginosa.
2. Versatile Applications: Used in systemic, localized, ophthalmic, and intestinal infections, as well as preoperative preparation for colorectal surgery.
3. Combination Therapy: Enhances postoperative infection prevention when combined with metronidazole or clindamycin.
4. Stable and Effective: Remains stable in water at 37°C for up to 5 days, ensuring reliable treatment.
Gentamicin sulfate is an aminoglycoside bactericidal antibiotic consisting of amino sugars and ligand molecules. As gentamicin's sulfate derivative, it possesses an antimicrobial range comparable to kanamycin. This compound is primarily employed against systemic or localized infections induced by Gram-negative organisms including Escherichia coli, Shigella dysenteriae, Klebsiella pneumoniae, Proteus species, and Pseudomonas aeruginosa. In ophthalmic applications, it treats conditions like conjunctivitis and keratitis.
For intestinal infections or preoperative bowel preparation in colorectal surgery, it can be administered orally. Additionally, when combined with metronidazole or clindamycin, it helps decrease postoperative infection risks in colon surgeries.
Parameters
Melting point | 218-237°C |
alpha | D25 +102° |
density | 1.000 g/cm3 |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days. |
form | |
color | colorless to light yellow |
Odor | odorless |
PH | 4.0-5.5 (0.1g/mL in H2O) |
optical activity | [α]20/D +110±8°, c = 1% in H2O |
biological source | Micromonospora purpurea |
Water Solubility | Soluble in water |
Merck | 134403 |
InChIKey | RDEIXVOBVLKYNT-HDZPSJEVSA-N |
CAS DataBase Reference | 1405-41-0(CAS DataBase Reference) |
EPA Substance Registry System | Gentamicin sulfate (1405-41-0) |
Safety Information | |
Hazard Codes | Xn |
Risk Statements | 42/43 |
Safety Statements | 23-36/37-45-22-24/25 |
WGK Germany | 2 |
RTECS | LY2625000 |
F | 3 |
HS Code | 29419010 |
Toxicity | LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black) |
