4-Hydroxycoumarin CAS#1076-38-6
Highly Versatile Intermediate: Based on a coumarin scaffold, it is widely used in the synthesis of diverse organic compounds.
Dual Reactivity: Possesses both electrophilic and nucleophilic properties, enabling flexible participation in various chemical reactions.
Defined Physical Characteristics: Exhibits a clear melting point (206°C) and needle-shaped crystalline form, supporting consistent handling and processing.
Good Solubility Profile: Easily soluble in ethanol, ether, and hot water, facilitating use in multiple solvent systems and applications.
Product Description: 4-Hydroxycoumarin (CAS# 1076-38-6)
4-Hydroxycoumarin is a derivative of coumarin and represents a highly versatile heterocyclic scaffold widely used in the synthesis of a variety of organic compounds. It exhibits both electrophilic and nucleophilic reactivity. The product appears as slightly yellow, needle-like crystals with a melting point of 206°C. It is readily soluble in ethanol, ether, and hot water, and produces a brown coloration when reacting with ferric chloride.
4-Hydroxycoumarin Chemical Properties
| Melting point | 211-213 °C (lit.) |
| Boiling point | 228.82°C (rough estimate) |
| Density | 1.1734 (rough estimate) |
| Vapor pressure | 0.02Pa at 25℃ |
| Refractive index | 1.4500 (estimate) |
| Storage temp | Store below +30°C. |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Form | Liquid |
| Pka | 4.50±1.00(Predicted) |
| Color | Clear colorless to slightly yellow |
| Water Solubility | PRACTICALLY INSOLUBLE |
| BRN | 129768 |
| InChIKey | VXIXUWQIVKSKSA-UHFFFAOYSA-N |
| LogP | 1.6-2.31 at 21.2℃ |
| CAS DataBase Reference | 1076-38-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Hydroxycoumarin(1076-38-6) |
| EPA Substance Registry System | 2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6) |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DJ3100000 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29322980 |
Product Application: 4-Hydroxycoumarin (CAS# 1076-38-6)
4-Hydroxycoumarin is widely used as an intermediate in the production of pharmaceuticals and pesticides. It serves as a key precursor for anticoagulant compounds such as dicoumarol, new anticoagulants, and warfarin, which belong to a class of oral anticoagulants. Among these, dicoumarol has a relatively long duration of action (4–7 days), while coumarin ethyl ester exhibits a shorter duration (2–3 days).
In addition, 4-hydroxycoumarin is utilized in the synthesis of certain rodenticides. It also has applications in the flavor and fragrance industry, as coumarin compounds are widely found in plants.
